蔡孟浩
生物工程专业：博士生导师/硕士生导师
生物化工专业：博士生导师/硕士生导师
生物与医药专业（生物工程领域）：工程博士生导师/工程硕士生导师
男，博士，教授，博士生导师，生物反应器工程全国重点实验室PI。获 (入选) 国家级青年人才计划(2021)、yl88858永利中国青年英才校长奖(2024)，上海市青年科技启明星计划A类 (2019)，yl88858永利中国青年英才培育计划A类 (2019) 等资助。担任中国微生物学会海洋分会专委会委员，中国生物化学与分子生物学学会海洋分会理事/委员，上海市生物工程学会合成生物学专委会委员、一碳生物技术专委会委员，上海市微生物学会咨询工作委员会委员、海洋微生物专委会委员，上海市化学化工学会生物工程与技术专委会委员，中华医学会航海医学分会海洋生物医药专委会委员，中国药学会海洋药物专委会青年委员会委员，并担任多家生物科技企业的技术顾问。
2006年毕业于yl88858永利中国理工优秀生部，获生物工程学士学位。2006-2011年中英 (布里斯托大学) 联合培养博士生，获得生物化工博士学位及留校任教，并相继入选副教授/硕导、博导 (破格)、教授。作为项目负责人，主持国家重点研发计划课题、国家自然科学基金项目、国家重大新药创制合作课题、国家863课题、上海科技创新行动计划项目、上海市农业科技创新项目、企业横向合作项目等30余项，完成多项专利转让。在Nature Synthesis、Science Advances、Nucleic Acids Research、JACS、PNAS、Metabolic Engineering等权威期刊发表论文90余篇，申请/公开中国发明专利27项及PCT专利3项 (已授权17项)。担任Bioresources and Bioprocessing青年编委、Molecules编委、Yeast专刊编委、Frontiers in Microbiology及Frontiers in Biotechnology and Bioengineering评审编委等，Nature Catalysis、Nature Synthesis、Nature Chemical Biology、Nature communications、Cell reports等期刊审稿人。主讲本科生微生物学，硕士生基因工程制药课程，曾参讲本科生分子生物学(英文)、博士生微生物细胞信号转导(英文)课程。
研究方向：
主要研究方向为微生物合成生物学，旨在通过新生物元件挖掘与遗传工具设计、新型底盘宿主改造与重塑、代谢途径重构与发酵优化调控，实现不同药/食源功能产物的高效发酵生产，解决其来源受限、制备困难、成本高等问题。
(一) 微生物底盘创制与药物生物合成：聚焦医药、食品安全菌株毕赤酵母，设计开发新型酵母底盘系统。解析转录调控机制，设计转录及翻译特色元器件，重构细胞代谢模式，开发多样化 (如无甲醇诱导、低甲醇强诱导、自定义信号强诱导等) 高版本底盘系统，促进复合碳源体系的高值化综合利用，实现重组蛋白药物、小分子天然产物、新型食品替代蛋白等功能分子的低碳高效表达。
(二) 药食源微生物底盘发酵调控与优化：依据微生物生理代谢特性，设计个性化发酵调控策略，优化产物途径模块的分配组装，开发定量化工程菌菌群共培养发酵策略，建立细菌、酵母菌、丝状真菌的发酵新工艺，实现目标分子产量提升1100多倍，实现从实验室小试优化到工厂中试制备的一体化体系，加速推进候选功能分子的产业化应用。
承担项目（负责人）：
国家重点研发计划课题；国家特殊支持人才计划；国家自然科学基金；上海市探索者计划项目；上海市农业科技创新项目；上海市青年科技启明星计划；上海科技创新行动计划基础研究领域合成生物学专项；国家863项目课题；国家重大新药专项课题等。
发表论文 (*通讯作者, #共同第一)：
代表性论文：
1. Qian Z, Yu H, Song C, Zhang Y, Liu Q, Qu X, Ye M*, Qiao X*, Cai M*. Biosynthesis of plant vitexin-derived flavonoid glycosides in yeast. Nat Synth, Online.
2. Liu Q, Song L, Peng Q, Zhu Q, Shi X, Xu M, Wang Q, Zhang Y, Cai M*. A programmable high expression yeast platform responsive to user-defined signals. Sci Adv, 2022, 8: eabl5166.
3. Zhu Q, Liu Q, Yao C, Zhang Y, Cai M*. Yeast transcriptional device libraries enable precise synthesis of value-added chemicals from methanol. Nucleic Acids Res, 2022, 50(17):10187-10199.
4. Zhang M, Bao Y, Dai Z, Qian Z, Yu H, Zhou J, Chen Y, Wang K, Cai M*, Ye M*. Molecular and structural characterization of a chalcone di-C-methyltransferase RdCMT from Rhododendron dauricum and its application in de novo biosynthesis of farrerol in Pichia pastoris. J. Am. Chem. Soc. 2025, 147:17132−17143.
5. Guo Y, Zhou L, Lai W, Qian Z, Yu H, Cai M*. Metabolic and enzyme rewiring enables high-production of vanillin in unconventional yeast. Metab Eng, 2026, 93: 158–167.
6. Yao C, Yin Y, Li Q, Zhang H, Zhang Y, Shao Q, Qi Liu*, Ren Y, Cai M*. Nucleotide distribution analysis of 5’UTRs in genome-scale directs their redesign and expression regulation in yeast. Metab Eng, 2025, 88:113-123.
7. Liu Y, Bai C, Liu Q, Xu Q, Qian Z, Peng Q, Yu J, Xu M, Zhou X, Zhang Y, Cai M*. Engineered ethanol-driven biosynthetic system for improveing production of acetyl-CoA derived drugs in Crabtree-negative yeast. Metab Eng. 2019, 54: 275-284.
8. Liu Y, Tu X, Xu Q, Bai C, Kong C, Liu Q, Yu J, Peng Q, Zhou X, Zhang Y, Cai M*. Engineered monoculture and co-culture of methylotrophic yeast for de novo production of monacolin J and lovastatin from methanol. Metab Eng. 2018, 45:189-199.
9. Wang X, Wang Q, Wang J, Bai P, Shi L, Shen W, Zhou M, Zhou X, Zhang Y, Cai M*. Mit1 transcription factor mediates methanol signaling and regulates alcohol oxidase 1 er in Pichia pastoris. J Biol Chem. 2016, 291:6245-6261.
10. Ren Y, Liu Q, Liu H, Zhou X, Zhang Y, Cai M*. Engineering substrate and energy metabolism for living cell production of cytidine-5’-diphosphocholine. Biotechnol Bioeng. 2020, 117(5):1426-1435
其他论文：
11. Liu Q#, Li Y#, Tao L, Yang J, Zhang Y, Cai M*. Rational design and characterization of enhanced alcohol-inducible synthetic ers in Pichia pastoris. Appl Environ Microb. 2025, 91(1):e02191-24.
12. Shao Q, Yao C, Wang X, Han B, Liu Q*, Cai M*. Heterologous expression and functional characterization of a truncated marine alginate lyase. Appl Biochem Biotechnol, 2025, 197:7694-7710.
13. Han B, Shao Q, Zhang Y, Liu Q*, Cai M*. Characterization and development of salt-resistant Aspergillus oryzae for marine-derived enzyme expression. Appl Biochem Biotechnol, 2025, 197:7258-7275.
14. Zhou J, Long H, Guo Y, Lu J, Wang N, Liu H, Zhou X, Cai M*. Glutamate-related nitrogen metabolism regulates cold-adaptive synthesis of red pigment in polar fungus Geomyces sp. WNF-15A. J Biotechnol. 2025, 404:121-131.
15. Lv W, Cai M*. Advancing recombinant protein expression in Komagataella phaffii: opportunities and challenges. FEMS Yeast Res. 2025, 25:foaf010.
16. Zhang Y, Wang X, Han B, Yao C, Liu Q*, Cai M*. Engineered folding and secretion for expression improvement of α-amylase in Komagataella phaffii. Food Bioeng. 2025, 4:3–14.
17. Gong X, Ye K, Xu M, Qian Z, Liu Q, Wang X, Zhou X, Liu H, Cai M*. Heavy chain variants affect light and heavy chains assembly of monoclonal antibody expressed by Pichia pastoris. Prep. Biochem. Biotechnol. 2025, 24:1-8.
18. Liu Q, He Z, Cai M*. Transcriptome analysis reveals methanol metabolism variations for the growth damage caused by overexpression of chimeric transactivators in Pichia pastoris. Synth Syst Biotechnol. 2025, 10(1):133-139.
19. Kang Y#, Qian,Z#, Yu H, Lu J, Zhao Q, Qiao X, Ye M, Zhou X, Cai M*. Programmable biosynthesis of plant-derived 4′-deoxyflavone glycosides by an unconventional yeast consortium. Small Methods. 2024, 2301371.
20. Ren Y, Han B, Wang S, Wang X, Liu Q*, Cai M*. De novo biosynthesis and nicotinamide biotransformation of nicotinamide of nicotinamide mononucleotide by engineered yeast cells. Microb Biotechnol. 2024, 17:e70048.
21. Long H, Zhou J, Ren Y*, Lu J, Wang N*, Liu H, Zhou X, Cai M*. Comparative omics directed gene discovery and rewiring for normal temperature-adaptive red pigment synthesis by polar psychrotrophic fungus Geomyces sp. WNF-15A. Synth Syst Biotechnol, 2024, 9(4):842-852.
22. Qian Z, Yu J, Chen X, Kang Y, Ren Y, Liu Q, Lu J, Zhao Q*, Cai M*. De novo production of the plant 4’-deoxyflavones baicalein and oroxylin A from ethanol in Crabtree-negative yeast. ACS Synth Biol. 2022, 11(4):1600-1612.
23. Lu F, Ren Y, Ding L, Lu J, Zhou X, Liu H, Wang N, Cai M*. Minos and Restless transposon insertion mutagenesis of psychrotrophic fungus for red pigment synthesis adaptive to normal temperature. Bioresourc Bioproc, 2022, 9:118.
24. Ding L, Huang H, Lu F, Lu J, Zhou X, Zhang Y, Cai M*. Transposon insertion mutation of Antarctic psychrotrophic fungus for red pigment production adaptive to normal temperature. J Ind Microbiol Biotechnol. 2021, 0: kuab073.
25. Ren Y, Liu Q, Liu H, Zhou X, Zhang Y, Cai M*. High-level living cell production of cytidine-5’-diphosphocholine in metabolically engineered yeast. J Biotechnol. 2021, 341:129-136.
26. Wen J, Tian L, Xu M, Zhou X, Zhang Y, Cai M*. A synthetic malonyl-CoA metabolic oscillator in Komagataella phaffii. ACS Syn Biol. 2020, 9:1059-1068.
27. Huang H, Ding L, Lu J, Wang N, Cai M*. Combinatorial strategies for production improvement of red pigments from Antarctic fungus Geomyces sp.. J Food Sci. 2020, 85(10):3061-3071.
28. Bai C, Liu Y, Chen X, Qian Z, Liu H, Zhou X, Zhang Y, Cai M*. Fungal statin pump protein improves monacolin J efflux and regulates its production in Komagataella phaffii. Bioresourc Bioprocess. 2020, 7:32.
29. Wen J, Tian L, Liu Q, Zhang Y, Cai M*. Engineered dynamic distribution of malonyl-CoA flux for improving polyketide biosynthesis in Komagataella phaffii. J Biotechnol. 2020, 320: 80-85
30. Bai C, Liu Y, Chen X, Qian Z, Liu H, Zhou X, Zhang Y, Cai M*. Fungal statin pump protein improves monacolin J efflux and regulates its production in Komagataella phaffii. Bioresourc Bioprocess. 2020, 7:32
31. Xu Q, Bai C, Liu Y, Song L, Tian L, Yan Y, Zhou J, Zhou X, Zhang Y, Cai M*. Modulation of acetate utilization in Komagataella phaffii by metabolic engineering of tolerance and metabolism. Biotechnol Biofuels. 2019, 12:61.
32. Liu Q#, Shi X#, Song L, Liu H, Zhou X, Wang Q, Zhang Y, Cai M*. CRISPR-Cas9-mediated genomic multiloci integration in Pichia pastoris. Microb Cell Fact. 2019, 18:144.
33. Kong C, Huang H, Xue Y, Liu Y, Peng Q, Liu Q, Yin Y, Zhou X, Zhang Y, Cai M*. Heterologous pathway assembly reveals molecular steps of fungal terreic acid biosynthesis. 2018, Sci Rep. 2018:2116.
34. Wang J, Wang X, Shi L, Zhang Y, Zhou X*, Cai M*. Reduced methanol input induces increased protein output by AOX1 er in a trans‑acting elements engineered Pichia pastoris. J Ind Microbiol Biotechnol. 2018, 45:25-30.
35. Shi L, Wang X, Wang J, Zhang P, Qi F, Cai M*, Zhang Y, Zhou X*. Transcriptome analysis of Δmig1Δmig2 mutant reveals their roles in methanol catabolism, peroxisome biogenesis and autophagy in methylotrophic yeast Pichia pastoris. 2018, Gen. Genom. 40:399–412.
36. Liu Y, Bai C, Xu Q, Yu J, Zhou X, Zhang Y, Cai M*. Improved methanol‑derived lovastatin production through enhancement of the biosynthetic pathway and intracellular lovastatin efflux in methylotrophic yeast. Bioresour. Bioprocess. 2018,5:22
37. Wang J, Wang X, Shi L, Qi F, Zhang P, Zhang Y, Zhou X*, Song Z*, Cai M*. Methanol-independent protein expression by AOX1 er with trans-acting elements engineering and glucose-glycerol-shift induction in Pichia pastoris. Sci Rep. 2017, 7:41850.
38. Xue Y, Kong C, Shen W, Bai C, Ren Y, Zhou X, Zhang Y, Cai M*. Methylotrophic yeast Pichia pastoris as a chassis organism for polyketide synthesis via the full citrinin biosynthetic pathway. J Biotechnol. 2017, 242:64-72.
39. Wu Y, Ren Y, Zhou X, Cai M*, Zhang Y*. Transcription factor Agseb1 affects development, osmotic stress response, and secondary metabolism in marine-derived Aspergillus glaucus. J. Basic Microbiol. 2017, 57:873-882 (cover article).
40. Huang M, Gao Y, Zhou X, Zhang Y, Cai M*. Regulating unfolded protein response activator HAC1p for production of thermostable raw-starch hydrolyzing α-amylase in Pichia pastoris. Bioproc. Biosyst. Eng. 2017, 40:341-350.
41. Gao Y, Huang M, Sun X, Zhang X, Zhang Y, Zhou X*, Cai M*. Single-site mutation of C363G or N463T strengthens thermostability improvement of IG181-182 deleted acidic α-amylase from deep-sea thermophile Geobacillus sp. Food Biotechnol. 2017, 31:57-71.
42. Xiao S, Gao Y, Wang X, Shen W, Wang J, Zhou X, Cai M*, Zhang. Peroxisome-targeted and tandem repeat multimer expressions of human antimicrobial peptide LL37 in Pichia pastoris. Prep Biochem Biotechnol. 2017, 47:229-235.
43. Liu S, Li J, Wu Y, Ren Y, Liu Q, Wang Q, Zhou X, Cai M*, Zhang Y. De novo transcriptome sequencing of marine-derived Aspergillus glaucus and comparative analysis of metabolic and developmental variations in response to salt stress. Gen Genom. 2017, 39:317-329.
44. Zhang X, He H, Yin Y, Zhou W, Cai M*, Zhou X, Zhang Y. A light–dark shift strategy derived from light-responded metabolic behaviors for polyketides production in marine fungus Halorosellinia sp.. J Biotechnol. 2016, 221:34-42.
45. He H, Xue Y, Xu N, Yin Y, Lu J, Cai M*, Zhang Y. A novel pH–precursor–glucose synergic control strategy for dinactin biosynthesis by an arctic actinomycete Streptomyces sp. Process Biochem. 2016, 51:1911-1918.
46. Shen C, Xu N, Gao Y, Sun X, Yin Y*, Cai M*, Zhou X, Zhang Y. Stimulatory effect of ethanol on libertellenone H biosynthesis by Arctic fungus Eutypella sp. D-1. Bioproc. Biosyst. Eng. 2016, 39:353-360.
47. Wang X, Cai M*, Shi L, Wang Q, Zhu J, Wang J, Zhou M, Zhou X, Zhang Y. PpNrg1 is a transcriptional repressor for glucose and glycerol repression of AOX1 er in methylotrophic yeast Pichia pastoris. Biotechnol Lett. 2016, 38:291-298.
48. Jiang T, Cai M*, Huang M, He H, Lu J, Zhou X, Zhang Y. Bioprocess exploration for thermostable α-amylase production of a deep-sea thermophile Geobacillus sp. in high temperature bioreactor. Prep Biochem Biotechnol. 2016, 46:620-627.
49. Wang M, He H, Na K, Cai M*, Zhou X, Zhao W, Zhang Y. Designing novel glucose/ornithine replenishment strategies by biosynthetic and bioprocess analysis to improve fibrinolytic FGFC1 production by the marine fungus Stachybotrys longispora. Process Biochem. 2015, 50:2012-2018
50. Jiang T, Cai M*, Huang M, He H, Lu J, Zhou X, Zhang Y. Characterization of a thermostable raw-starch hydrolyzing a-amylase from deep-sea thermophile Geobacillus sp. Protein Expres Purif. 2015, 114:15-22.
51. Zhou J, He H, Wang X, Lu J, Zhou X, Cai M*, Zhang Y. Optimization of nutrients for dinactin production by a marine Streptomyces sp. from the High Latitude Arctic. Biotechnol Bioproc Eng. 2015, 20:725-732.
52. Cai M#, Zhang Y#, Hu W, Shen W, Yu Z, Zhou W, Jiang T, Zhou X*, Zhang Y. Genetically shaping morphology of the filamentous fungus Aspergillus glaucus for production of antitumor polyketide aspergiolide A. Microb Cell Fact. 2014, 13:73.
53. Yu Z, Cai M*, Hu W, Zhang Y, Zhou J, Zhou X, Zhang Y. A cyclin-like protein, ClgA, regulates development in Aspergillus nidulans. Res Microbiol. 2014, 165:462-467.
54. Zhou W, Cai M*, Na K, Shen C, Zhang X, Zhou X, Zhao W, Zhang Y. pH-dependent accumulation of anticancer compound on mycelia in fermentation of marine fungus. J Ind Microbiol Biotechnol. 2014, 41: 1169-1173.
55. Zhou J, Cai M*, Jiang T, Zhou W, Shen W, Zhou X, Zhang Y. Mixed carbon source control strategy for enhancing alginate lyase production by marine Vibrio sp. QY102. Bioproc Biosyst Eng. 2014, 37:575-584.
56. Gao L, Cai M*, Shen W, Xiao S, Zhou X, Zhang Y. Engineered fungal polyketide biosynthesis in Pichia pastoris: a potential excellent host for polyketide production. Microb Cell Fact. 2013, 12:77.
57. Zhou W, Cai M*, Zhou J, Jiang T, Zhou J, Wang M, Zhou X*, Zhang Y. Nutrition and bioprocess development for efficient biosynthesis of an antitumor compound from marine-derived fungus. J Ind Microbiol Biotechnol. 2013, 40:1131-1142.
58. Cai M, Fang Z, Niu C, Zhou X*, Zhang Y. Light regulation on growth, development and secondary metabolism of marine-derived filamentous fungi. Folia Microbiol. 2013, 58: 537-546.
59. Cai M, Zhou X, Lu J, Fan W, Zhou J, Niu C, Kang L, Sun X, Zhang Y. An integrated control strategy for the fermentation of the marine-derived fungus Aspergillus glaucus for the production of anti-cancer polyketide. Mar Biotechnol. 2012, 14:665-671.
60. Cai M, Zhou X*, Sun X, Tao K, Zhang Y*. Statistical optimization of medium composition for aspergiolide A production by marine-derived fungus Aspergillus glaucus. J Ind Microbiol Biotechnol. 2009, 36: 381-389.
61. Cai M, Sun X, Zhou X*, Zhang Y*. Roles of cobalt in biosynthesis stimulation of a cytotoxic compound from marine-derived Aspergillus glaucus. Process Biochem. 2012, 12: 2267–2274.
62. Cai M, Zhou X, Lu J, Fan W, Niu C, Zhou J, Sun X, Kang L, Zhang Y. Enhancing aspergiolide A production from a shear-sensitive and easy-foaming marine-derived filamentous fungus Aspergillus glaucus by oxygen carrier addition and impeller combination in a bioreactor. Bioresourc Technol. 2011, 102: 3584-3586.
63. Cai M, Zhou X, Zhou J, Niu C, Kang L, Sun X, Zhang Y. Efficient strategy for enhancing aspergiolide A production by citrate feedings and its effects on sexual development and growth of marine-derived fungus Aspergillus glaucus. Bioresourc Technol. 2010, 101:6059-6068.
64. An D, Xiao Q, Zhang C, Cai M, Zhang Y, Weng H, Chen F, Xiao A*. Preparation, characterization, and application of high-whiteness agar bleached with hydrogen peroxide. Food Hydrocolloid. 2021, 113:106520
65. Chen H, Chen F, Xiao Q, Cai M, Yang Q, Weng H, Xiao A*. Structure and physicochemical properties of amphiphilic agar modified with octenyl succinic anhydride. Carbohyd Polym. 2021, 251:117031.
66. Xiao Q, Chen G, Zhang Y, Weng H, Cai M, Xiao A*. Evaluation of a novel self-emulsifiable dodecenyl succinylated agarose in microencapsulation of docosahexaenoic acid (DHA) through spray-chilling process. Int J Biol Macromol. 2020, 163:2314–2324.
67. Shi L, Wang J, Wang X, Zhang Y, Song Z, Cai M, Zhou X*. Transcriptome and metabolome analyses reveal global behaviour of a genetically engineered methanol-independent Pichia pastoris strain. Process Biochem. 2019, 76:46-54.
68. Zhang X, Gao Y, Yin Y*, Cai M, Zhou X, Zhang Y. Regulation of different polyketide biosynthesis by green light in an endophytic fungus of mangrove leaf. 3 Biotech. 2017, 7:363.
69. Zhang X, Gao Y, Yin Y*, Cai M, Zhou X, Zhang Y. Effective pH pretreatment and cell disruption method for real-time intracellular enzyme activity assay of a marine fungus covered with pigments. Prep Biochem Biotechnol. 2017, 47:211-217.
70. Shen W, Xue Y, Liu Y, Kong C, Wang X, Huang M, Cai M, Zhou X, Zhang Y, Zhou M*. A novel methanol-free Pichia pastoris system for recombinant protein expression. Microb Cell Fact. 2016, 15:178.
71. Shen W, Kong C, Xue Y, Liu Y, Cai M, Zhang Y, Jiang T, Zhou X, Zhou M. Kinase screening in Pichia pastoris identified promising targets involved in cell growth and alcohol oxidase 1 er (PAOX1) regulation. PLoS ONE, 2016, 11:e0167766.
72. Yin Y*, Cai M, Zhou X, Li Z, Zhang Y*. Polyketides in Aspergillus terreus: biosynthesis pathway discovery and application. Appl Microbiol Biotechnol. 2016, 100:7787-7798.
73. Wang S, Liu Q*, Cai M, Wang Q, Zhang Y. Fermentation preparation of recombinant Vibrio anguillarum vaccine with heterogeneous antigen display. Prep Biochem Biotechnol. 2013, 43:79-94.
74. Davison J, al Fahad A, Cai M, Song Z, Yehia SY, Lazarus CM, Bailey AM, Simpson TJ, Cox RJ. Genetic, molecular, and biochemical basis of fungal tropolone biosynthesis. Proc Natl Acad Sci U S A. 2012, 109: 7642-7647.
75. Niu C, Cai M, Zhang Y, Zhou X*. Biosynthetic origin of the carbon skeleton of a novel anti-tumor compound, haloroquinone, from a marine-derived fungus, Halorosellinia sp. Biotechnol Lett. 2012, 34:2119-2124.
76. Kang L, Cai M, Yu C, Zhang Y, Zhou X*. Improved production of the anticancer compound 1403C by glucose pulse feeding of marine Halorosellinia sp. (No. 1403) in submerged culture. Bioresourc Technol. 2011, 102:10750-10753.
77. Yu C, Cai M, Kang L, Zhang Y, Zhou X*. Significance of seed culture methods on mycelial morphology and production of a novel anti-cancer anthraquinone by marine mangrove endophytic fungus Halorosellinia sp. (No. 1403). Process Biochem. 2012, 47:422-427.
78. Fang Z, Zhang Y, Cai M, Zhang J, Zhang Y, Zhou X*. Improved gene targeting frequency in marine-derived filamentous fungus Aspergillus glaucus by disrupting ligD. J Appl Genet. 2012, 53:355–362.
79. Tu PG, Wang Y, Cai M, Zhou X*, Zhang Y*. Co-expressions of protein tyrosine kinases EGFR-2 and PDGFRβ with protein tyrosine phosphatase 1B in Pichia pastoris. J Microbiol Biotechnol. 2014, 24: 152-159.
80. Sun X, Zhou X*, Cai M, Tao K, Zhang Y*. Identified biosynthetic pathway of aspergiolide A and a novel strategy to increase its production in a marine-derived fungus Aspergillus glaucus by feeding of biosynthetic precursors and inhibitors simultaneously. Bioresourc Technol. 2009, 100: 4244-4251.
81. Sun X, Zhou X*, Cai M, Zhou J, Zhang Y*. Significant stimulation of o-phthalic acid in biosynthesis of aspergiolide A by a marine fungus Aspergillus glaucus. Bioresourc Technol. 2010, 101: 3609-3616.
82. Tao K, Du L, Sun X, Cai M, Zhu T, Zhou X*, Gu Q, Zhang Y. Biosynthesis of aspergiolide A, a novel antitumor compound by a marine-derived fungus Aspergillus glaucus via the polyketide pathway. Tetra Lett. 2009, 50: 1082-1085.
83. 于飞祥, 刘海峰, 任燕娜, 蔡孟浩*. 屋尘螨过敏原Der p 1在毕赤酵母中的重组表达与纯化. yl88858永利中国学报(自然科学版), 2024, 50(4): 543-549.
84. 刘启, 钱芷兰, 宋丽丽, 要超颖, 徐名强, 任燕娜, 蔡孟浩*. 巴斯德毕赤酵母底盘细胞的工程化改造及应用. 合成生物学. 2022, 3(6):1150-1173
85. 朱弈, 徐名强, 任燕娜*, 蔡孟浩*. 赖氨酰内切酶在大肠杆菌中的重组表达、复性及纯化. yl88858永利中国学报(自然科学版), 2022, 接收.
86. 陈鑫洁, 钱芷兰, 刘启, 赵清, 张元兴, 蔡孟浩*. 毕赤酵母底盘芳香族氨基酸合成途径改造生产肉桂酸及对香豆酸. 2021, 41(10):52-61.
87. 卢凤宁, 张元兴, 蔡孟浩*. 极地酵母菌的发现与应用. 2021, 33(3):315-324.
88. 彭强强, 刘启, 徐名强, 张元兴, 蔡孟浩*. 新型重组毕赤酵母产人胰岛素前体的表达工艺研究. 中国生物工程杂志. 2019, 39(07):48-55.
89. 李佳欣，刘绍梅，任燕娜，周祥山，蔡孟浩*，张元兴. 海洋灰绿曲霉AgveA基因响应盐度胁迫的功能分析. yl88858永利中国学报(自然科学版). 2018, 44:650-660.
90. 胡伟，李佳欣，李晓霞，蔡孟浩*，周祥山*，张元兴. 剪切敏感型海洋灰绿曲霉AgugtA和AgugeA基因的克隆及功能分析. yl88858永利中国学报(自然科学版). 2015, 41: 455-463.
91. 李晓霞, 蔡孟浩*, 胡伟, 李佳欣, 周祥山*, 张元兴. 海洋灰绿曲霉聚酮合酶基因的克隆与序列分析. yl88858永利中国学报(自然科学版). 2014, 40: 579-585.
92. 齐飞, 蔡孟浩, 周祥山*, 张元兴. 基于rna-seq技术的毕赤酵母基因组重注释及新型强启动子的发现与序列分析. yl88858永利中国学报(自然科学版). 2014, 40:167-175.
93. 柏鹏, 蔡孟浩, 周祥山*, 张元兴. 葡萄糖诱导型AOX1启动子毕赤酵母突变株B5的筛选. 工业微生物2013, 43:69-72.
94. 牛传朋, 蔡孟浩, 李晓霞, 周祥山*, 张元兴. 海洋真菌Xylaria sp.(No.2508)生产xyloketal B的发酵优化.工业微生物 2012, 42:43-47.
95. 张盈, 沈伟, 蔡孟浩, 周祥山*, 张元兴. 海洋真菌灰绿曲霉地标蛋白编码基因AgTeaA的克隆与序列分析. 生物技术通报 2011, 12:157-161.
96. 康丽, 蔡孟浩, 范卫民, 陆健, 周祥山*, 张元兴. 海洋红树林内生真菌产抗肿瘤活性化合物1403C发酵条件的优化. 生物技术通报 2011, 12:199-204.
专著：
1. Qian Z, Liu Q, Cai M*. Investigating fungal biosynthetic pathways using Pichia pastoris as a heterologous host. In: Skellam E. (eds) Engineering Natural Product Biosynthesis. Methods in Molecular Biology, 2022, 2489:115-127. Humana, New York, NY.
2. 蔡孟浩, 周祥山, 张元兴. 海洋微生物活性产物规模化发酵技术. In: 于广利, 谭仁祥主编. 海洋天然产物与药物研究开发. 科学出版社. 2016.
联系方式：
E-mail: cmh022199@ecust.edu.cn