赵莉
生物工程专业：硕士生导师
食品科学与工程专业：硕士生导师
生物与医药专业（生物工程领域）：硕士生导师
个人简介
赵莉，女；工学博士，副教授。2008年博士毕业于yl88858永利中国。2018.3-2019.3美国佐治亚理工学院(Georgia Institute of Technology) 访问学者。
研究方向：
1. 特殊生境功能微生物的筛选及其活性代谢产物的挖掘与应用；
2. 重要平台化合物（有机酸、多元醇）的绿色生物合成途径解析与产业化转化；
3. 重组酶及蛋白药物高效表达系统的发酵代谢调控与分子机制研究。
科研项目：
1. 双菌两步法产3-羟基丙酸机制解析及高效体系构建(NO.21506017)，国家自然科学基金，2016.1-2018.12，主持
2. 1,3-丙二醇氧化还原酶强化对克雷伯杆菌生长代谢的影响机制(NO.13ZR1412100)，上海市自然科学基金，2013.7-2016.6，主持
3. 乳酸菌发酵食用酵素产品开发，上海清美绿色食品（集团）有限公司，2024.10-2026.10，主持
4. 计算机高通量筛选具抗衰作用活性物质，资生堂（中国）投资有限公司，2025.3-2026.3，主持
5. 具情绪调节作用精油分子的虚拟高通量筛选，资生堂（中国）投资有限公司，2023.8-2023.12，主持
6. 甘油生物酶法合成1,3-丙二醇，派尔科化工材料有限公司，2025.10-2026.10，主持
7. 护肤生物活性肽开发研究，上海皓以科技有限公司，2021.8-2023.8，主持
8. 几种工业用酶酶库的构建及酶的功能研究，生物反应器国家重点实验室特别资助项目，2010.1-2011.12，主持
教学工作：
《食品微生物学实验》，本科专业必修课程，
《食品原料安全控制》，本科专业必修课程，
《发酵食品》，本科专业选修课程，
《食品营养与健康》，本科公共选修课程
代表性论文（*通讯作者）：
1. Yuzhi Zhang, Jinnan Luo, Lei Du, Bei Gao, Li Zhao*, Jingli Xie*, A novel strategy of gifting antibacterial activity to the waste from food processing: Probiotic fermentation combining with enzymatic hydrolysis of rice wine residue, Food Bioscience, 2025,69: 106899.
2. Anqi Li, Minli Ge, Lingzi He, Wenfeng Zhao, Lei Du, Li Zhao*, Jingli Xi, Evaluation of vaginal probiotic properties of food-derived lactic acid bacteria: the inhibition of gardnerella vaginalis and the adhesion capability, Food Bioengineering, 2025, 4: 225-235.
3. Deyi Yin#, Li Zhao#, Sijing Deng, Yaqi Xie, Kum-Song Ro, Zeyong Yang, Lei Du*, Jingli Xie*, Dongzhi Wei, Lactiplantibacillus plantarum X7022 plays roles on aging mice with memory impairment induced by D-galactose through restoring neuronal damage, relieving inflammation and oxidative stress, Probiotics Antimicrob Proteins, 2025, 17: 1-14.
4. Kum-Song Ro#, Li Zhao#, Yangting Hu, Minli Ge, Lei Du*, Jingli Xie*, Anti-hyperuricemic properties and mechanism of Lactiplantibacillus plantarum X7023, Process Biochemistry, 2024,36: 26-37.
5. Xiaoying Xie#, Kum-Song Ro#, Huiling Wu, Lei Du, Li Zhao*, Jingli Xie*, Dongzhi Wei, A novel γ-aminobutyric acid biosynthetic pathway in Lentilactobacillus curieae，CCTCC M 2011381T，Process Biochemistry，2023,124: 160-167.
6. Li Zhao, Jiawei Zhu, Kum-Song Ro, Jingli Xie*, Dongzhi Wei*，Discovery of a novel acrylic acid formation pathway in Gluconobacter oxydans and its application in biosynthesis of acrylic acid from glycerol，Process Biochemistry, 2022,18: 182-189.
7. Kum-Song Ro, Ying Chen, Lei Du, Lixin Wang, Li Zhao*, Jingli Xie*, Dongzhi Wei，Improvement of S-allyl-L-cysteine content, probiotic properties and constipation prevention effect of black garlic by the lactic acid bacteria fermentation, Process Biochemistry, 2022,115: 110-117.
8. Guang Liu, Yafan Liu, Kum-Song Ro, Lei Du, Ya-Jie Tang， Li Zhao*, Jingli Xie, Dongzhi Wei ，Genomic characteristics of a novel strain Lactiplantibacillus plantarum X7021 isolated from the brine of stinky tofu for the application in food fermentation, LWT-Food Science and Technology, 2022,156: 113054
9. Wencheng Liang, Mingli Jiang, Junyong Zhang, Xiaoming Dou, Yan Zhou, Yun Jiang, Li Zhao*, Meidong Lang∗, Novel antibacterial cellulose diacetate-based composite 3D scaffold as potential wound dressing, Journal of Materials Science & Technology, 2021,89: 225-232.
10. Jiawei Zhu, Jingli Xie, Liujing Wei, Jinping Lin, Li Zhao*, Dongzhi Wei*，Identification of the enzymes responsible for 3-hydroxypropionic acid formation and their use in improving 3-hydroxypropionic acid production in Gluconobacter oxydans DSM 2003, Bioresource Technology, 2018,265: 328-333.
11. Yunlong Sun, Changlin Chen, Heng Xu, Kun Lei, Guanzhe Xu, Li Zhao*, Meidong Lang*, Surface modification of silicon wafer by grafting zwitterionic polymers to improve its antifouling property, Applied Surface Science, 2017,419: 642-649.
12. Yunlong Sun, Changlin Chen,·Heng Xu,·Guanzhe Xu, Li Zhao*, Meidong Lang*, Synthesis and antibacterial performance of functional organic-inorganic silica nanocomposites based on novel zwitterionic polymer, Journal of Inorganic and Organometallic Polymers and Materials, 2017, 27(5): 1351-1364.
13. Li Zhao, Jinping Lin, Hualei Wang, Jingli Xie, Dongzhi Wei*, Development of a two-step process for production of 3-hydroxypropionic acid from glycerol using Klebsiella pneumoniae and Gluconobacter oxydans, Bioprocess and Biosystems Engineering, 2015, 38(12): 2487-2495.
14. Zhao Li, Zheng Yu, Ma Xingyuan*, Wei Dongzhi*, Effects of over-expression of glycerol dehydrogenase and 1,3-propanediol oxidoreductase on bioconversion of glycerol into 1,3-propandediol by Klebsiella pneumoniae under micro-aerobic conditions, Bioprocess and Biosystems Engineering, 2009,32(3): 313-320.
15. Zhao Li, Ma Xingyuan, Zheng Yu, Zhang Jianguo, Wei Guodong, Wei Dongzhi*, Over-expression of glycerol dehydrogenase and 1,3-propanediol oxidoreductase in Klebsiella pneumoniae and their effects on conversion of glycerol into 1,3-propanediol in resting cell system, Journal of Chemical Technology and Biotechnology, 2009,84(4): 626-632.
专利：
1. 谢静莉, 赵莉, 杜磊, 苏沙沙. 一种贝莱斯芽孢杆菌MY-8及其在防治植物病原菌中的应用. 202510134145.9
2.谢静莉, 赵莉, 杜磊, 苏沙沙. 一种白芽孢杆菌MY-7及其在防治植物病原菌中的应用. 2025101268326
3.谢静莉, 赵莉, 杜磊, 苏沙沙. 一种唾液链球菌（Streptococcus salivarius）MY-6及其应用. 202411047496.8
4.谢静莉, 赵莉, 苏沙沙. 一种嗜热艾氏滨芽孢杆菌Bacillus aestuarii MY-4及其在固体废弃物资源化利用中的应用. 202410802494.9
5.谢静莉, 杜磊, 赵莉, 苏沙沙. 一种积雪草发酵产物及其应用. 202511350284.1
6.谢静莉, 杜磊, 赵莉, 苏沙沙. 一种款冬花提取物及其在情绪调节和抑郁症治疗中的应用. 202510916222.6
7.谢静莉, 杜磊, 赵莉, 苏沙沙. 一种抗氧化肽及其应用. 202510916221.1
8.谢静莉, 杜磊, 赵莉, 苏沙沙. 一种I型5α-还原酶抑制肽及其组合物和用途. 202510571322.X
参编教材：
《食品微生物检验学》中国轻工业出版社，2019.2，中国轻工业“十三五”规划教材
《现代食品微生物学》科学出版社，2021.11，科学出版社“十三五”高等教育研究生规划教材
联系方式：
上海市徐汇区梅陇路130号，邮编：200237
办公室：实验十八楼1113室
手机号：13817206675
邮箱：zhaoli@ecust.edu.cn